Who Can Benefits
- Preventive medicine
- Anti-aging
- Nutrition
- Sport
- Pharmaceuticals - Personalized medicine
- Nutraceuticals
- Cosmeceuticals
In normal physiological situations, free radicals are constantly produced in our organism and their production is regulated by an efficient antioxidant defense (vitamins, oligoelements, proteins and enzymes) to prevent excessive cell damage.
Modern life however confronts us with pollution, prolonged exposure to sunlight, consumption of alcohol and medications, unbalanced physical activities, smoking, and oxidant deficient diets, obesity, all situations that leads to a weakening of our antioxidant defenses and also cause cell damage. Our antioxidant defense system also weaken with aging.
Several large epidemiological studies have shown that low circulating levels of antioxidants and oligoelements are closely linked to a higher incidence of cardiovascular diseases, cancers et more generally all diseases linked to aging. Moreover experimental and epidemiological studies also showed that complementary supplementation of antioxidant vitamins or selenium in patients with antioxidant deficiencies can decrease the incidence of cardiovascular diseases, several types of cancer and arteriosclerosis.
A regular diagnostic of the balance between oxidants and antioxidants is a key tool to achieve an optimal expression of our physical and mental potentials.
Most diseases associated with the human aging process are known to have a strong oxidative stress component. Thus, pharmaceutical drugs and other therapies that act to lower oxidative stress, represent a major approach in treating these diseases as well as intervening with the aging process itself. We believe that this new field of oxidative stress diagnostics, prevention, and treatment will have a significant impact on the economics, science and the practice of medicine.
A regular diagnostic of the balance between oxidants and antioxidants is a key tool to achieve an optimal expression of our physical and mental potentials during the whole life.
Food provides not only essential nutrients needed for life but also other bioactive compounds for health promotion and disease prevention. Previous epidemiologic studies have consistently shown that diet plays a crucial role in the prevention of chronic diseases. Consumption of fruit and vegetables, as well as grains, has been strongly associated with reduced risk of diseases with a strong oxidative stress component: cardiovascular disease, cancer, diabetes, Alzheimer disease, cataracts, and age-related functional decline. Heart disease, cancer, and stroke are the top 3 leading causes of death in most industrialized countries. It is estimated that one third of all cancer deaths in the United States could be avoided through appropriate dietary modification. This convincing evidence suggests that a change in dietary behavior such as increasing consumption of fruit, vegetables, and grains is a practical strategy for significantly reducing the incidence of chronic diseases.
Probiox diagnostic products and services are used to assess the nutritional supply of antioxidants and to adapt diets to prevent or to treat an oxidative stress.
Regular physical activity, associated with a balanced diet, is known as an important factor for health. However, exhaustive and/or intense physical activity can induce diseases, injuries, and chronic fatigue, which can lead to the overtraining syndrome, partially because of the toxicity of free radicals. Free radicals, which are highly produced during physical exercise, are involved in muscular fatigue, many diseases and aging. Antioxidants are components that suppress free radicals and heir harmful effects. Physical activity increases the free radical production and the antioxidant utlisation. Nutrition provides an important part of the antioxidant; however, insufficient micronutrients supply is often reported in athletes.
Training provokes a decrease of oxidative stress, which is caused by an increase of the efficiency of the antioxidant system in response to the supplementary production of free radicals during exercise. Nevertheless, the training program must be sufficiently long and intenses to trigger a subsequent adaptive response of the antioxidant system and a decrease of oxidative stress.
A regular diagnostic of the balance between oxidants and antioxidants is a key tool to achieve an optimal expression of the physical potentials during sport activities. Probiox is also developing new rapid diagnostics tests to facilitate this measurement.
Pharmaceuticals - Personalized medicine
Several pharmaceuticals companies are developing new drugs either to activate oxidative stress (for example in cancer treatment) or to treat or prevent
Probiox's expertise, new molecular products, and database of thousands of oxidative stress status are helping pharmaceuticals companies to evaluate the efficacy of their products aimed to oxidative stress prevention and treatment, or their in vivo an in vitro toxicity.
Personalized medicine uses new methods of molecular analysis to better manage a patient’s disease or predisposition toward a disease. It aims to achieve optimal medical outcomes by helping physicians and patients choose the disease management approaches likely to work best in the context of a patient’s genetic and environmental profile. People vary from one another in many ways — what they eat, the types and amount of stress they experience, exposure to environmental factors, and their DNA. Many of these variations play a role in health and disease. Personalized medicine hopes to use these variations — both in the patient and in the molecular underpinnings of the disease itself — to develop new treatments and to identify the sub-groups of patients for whom they will work best. It can also help determine which groups of patients are more prone to developing some diseases and, ideally, help with the selection of lifestyle changes and/or treatments that can delay onset of a disease or reduce its impact.
Personalized medicine is poised to transform healthcare over the next several decades. New diagnostic and prognostic tools will increase our ability to predict the likely outcomes of drug therapy, while the expanded use of biomarkers — biological molecules that indicate a particular disease state — could result in more focused and targeted drug development. Personalized medicine also offers the possibility of improved health outcomes and has the potential to make healthcare more cost-effective.
Cardiovascular disease and cancer are ranked as the first and second leading causes of death in the United States and in most industrialized countries. Regular consumption of fruit and vegetables is associated with reduced risks of diseases with a strong oxidative stress component: cardiovascular disease, cancer, diabetes, Alzheimer disease, cataracts, and age-related functional decline. Prevention is a more effective strategy than is treatment of chronic diseases. Functional foods that contain significant amounts of bioactive components may provide desirable health benefits beyond basic nutrition and play important roles in the prevention of chronic diseases.
Probiox's expertise, noew molecular products, and database of thousands of oxidative stress status are helping nutraceuticals companies to evaluate the efficacy of their products aimed to oxidative stress prevention and treatment.
The skin is frequently exposed to a constant assault of endogenous and exogenous damaging agents. Agents such as UV radiation, drugs, air pollutants, and heat and/or cold are continually challenging the protective character of the skin. In addition to these external insults, the skin also has to cope with endogenous mitogens, most importantly reactive oxygen species (ROS) and other free radicals. These species are continuously produced during physiological cellular metabolism. To counteract the harmful effects of ROS, the skin is equipped with an antioxidant system to maintain equilibrium between the pro-oxidants, or damaging agents, and the antioxidants, or protective agents; these antioxidants intervene at different levels in the protective process.
Probiox's expertise, new molecular products, and database of thousands of oxidative stress status are helping cosmeceuticals companies to evaluate the efficacy of their products aimed to skin oxidative stress prevention and treatment.